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In The News...
"Nutritional
Hormesis"
By DP Hayes
New York City Department of Health and Mental Hygiene, New York, NY USA
European Journal of Clinical Nutrition (2006), 1-13
Objective: Hormesis, the biological and
toxicological concept that small quantities have opposite effects from large
quantities, is reviewed with emphasis on its relevance to nutrition.
Results: Hormetic and other dose-response relationships are categorized,
depicted, and discussed. Evidence for nutritional hormesis is presented for
essential vitamin and mineral nutrients, dietary restriction, alcohol (ethanol),
natural dietary and some synthetic pesticides, some herbicides, and acrylamide.
Some of the different hormetic mechanisms that have been proposed are reviewed.
Conclusions: The credence and relevance of hormesis to nutrition are
considered to be established. The roles of hormesis in nutritional research and
in formulating nutritional guidelines are discussed
Sponsorship: The New York City Department of Health and Mental Hygiene.
European Journal of Clinical Nutrition advance online publication, 2 August
2006; doi:10.1038/sj.ejcn.1602507
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