International Dose-Response Society | Focusing on the Dose-Response in the Low-Dose Zone |

Instructions for Authors

General Information: Dose-Response, formerly Nonlinearity in Biology, Toxicology, and Medicine, is a quarterly peer-reviewed electronic journal devoted to the publication of original findings on the occurrence of nonlinear dose-response relationships across a broad range of biological disciplines including physiology, biochemistry, molecular biology, toxicology, radiation biology, pharmacology, medicine, experimental psychology, plant biology, as well as environmental and related sciences. In addition to descriptive experimental findings of nonlinear dose responses, particular interest will focus on experimental evidence providing a mechanistic understanding of nonlinear dose-response relationships. The journal also welcomes the submission of biologically motivated statistical modeling of nonlinear dose-response relationships. While the emphasis of the journal is on the publication of experimental findings, population-based epidemiological studies relating to nonlinearity are encouraged. In addition, the journal encourages submittal of mini-reviews on topics at the forefront of research interest. Finally, the journal is interested in receiving manuscripts that apply the concept of nonlinearity to current developments in drug and chemical testing procedures and in environmental, occupational, and medical risk assessment.

Managing Editor: Denise Leonard, University of Massachusetts, Environmental Health Sciences, Morrill Science Center 1, N344, 639 North Pleasant Street, Amherst, MA 01003; Telephone: 413-545-1239, email: dleonard@schoolph.umass.edu.

Manuscripts should be submitted at http://mc.manuscriptcentral.com/dose-response. After accessing the website, if you do not have an account, click the “create account” button and follow the instructions to create an account and log in. If you already have an account, you may log in. Once you are logged in, click the author button and then the button to submit a new manuscript. Follow the step-by-step instructions to submit your manuscript.

Please provide the names, complete addresses, telephone numbers, and email addresses of three potential reviewers for the manuscript.

Authors of published papers will receive a free pdf of their article. High-quality reprints of articles will also be available for purchase at the author’s page proof stage or any time thereafter.

Only original papers will be considered. Manuscripts are accepted for review with the understanding that the same work has not been published, that it is not under consideration for publication elsewhere, and that its submission for publication has been approved by all of the authors and by the institution where the work was performed and that any person cited as a source of personal communications has approved such citation. Written authorization may be required at the Editor’s discretion. Articles and any other material published in Dose-Response represent the opinions of the authors and should not be construed to reflect the opinions of the Editors or the Publisher.

Disclosure of all financial and personal relationships that might bias the work of the author(s) is required. This applies to original manuscripts, review articles, letters to the editor, commentaries, and any submissions to the journal. In such cases, please submit a conflict of interest notification page. If additional details are necessary, please include these in your cover letter. Please note in your cover letter if your study or research was sponsored and if so, by whom, and whatever role your sponsor had and/or currently has. If your study was funded by a group with a proprietary or financial interest in its results, please indicate that you had full access to your data and are completely responsible for its integrity and analysis.

The International Committee of Medical Journal Editors (ICMJE) has produced and updated the “Uniform Requirements for Manuscripts (URM) Submitted to Biomedical Journals”. Dose-Response adheres to these guidelines, which can be found at www.icmje.org.

Preparation of Manuscripts:

The entire manuscript must be typed double-spaced (including title page, text, references, footnotes, figure legends and tables). :

	Title page, abstract page, references and figure legends must be on separate pages. The title page must include the title, authors’ names and addresses, and the phone and fax numbers and email address of the corresponding author.
	All manuscripts must be accompanied by an abstract not to exceed 200 words as well as a list of three to six key (indexing) terms. The key terms must follow the abstract and be on the same page.
	A running head not to exceed 60 characters, including spaces, must appear only on the title page, placed near the bottom.
	Each page should contain line numbers in the left-hand margin.
	All pages must be numbered consecutively in the lower right-hand corner, starting with the title page and including pages containing tables and figure legends.
	Tables, figure legends and furnished art should be grouped together at the end of the manuscript to facilitate processing.
	Times Roman is the preferred typeface for printouts of manuscripts.
	Microsoft Word (Office 2003 or earlier) is the required program for submissions.

Authors should write in clear, concise English. The responsibility for all aspects of manuscript preparation rests with the authors. Extensive changes or rewriting of the manuscript will not be undertaken by the Editor.

It is the responsibility of the author to obtain permission to use previously published material. Permission must be obtained from the original copyright owner, which in most cases is the publisher.

Acknowledgments: Acknowledgments should be gathered into a brief statement at the end of the text. All sources of financial sponsorship are to be acknowledged, including the names of private and public sector sponsors. This includes government grants, corporate funding, trade associations and contracts.

References: References must follow the text and begin on a separate page, be double-spaced and alphabetized. Each line after the first of each reference must be indented, using the “hanging paragraph” format available in word processors. If there is more than one reference by one author or group of authors in the references, they must be placed in chronological order. Use small letters (1999a, b) for references published in the same year. Abbreviate journal titles according to the Chemical Abstracts Service Source Index (1985).

A. Journal Article:

Voss AK and Fortune JE. 1993. Estradiol-17-beta has a biphasic effect on oxytocin secretion by bovine granulose cells. Biol Reprod 48:1404-1409

Hall JL, Ye JM, Clark MG, and Colquhoun EQ. 1997. Sympathetic stimulation elicits increased or decreased VO2 in the perfused rat hindlimb via alpha 1-adrenoceptors. Am J Physiol 272:H2146-H2153

B. Document:

USEPA (U.S. Environmental Protection Agency). 1983. Health Assessment Document for Acrylonitrile. EPA-600/8-82-007F. Office of Health and Environmental Assessment, Washington, DC

C. Book:

Kondo S. 1993. Health Effects of Low-Level Radiation. Kinki University Press, Osaka, Japan

D. Chapter in an Edited Book:

Jegou B and Sharpe RM. 1993. Paracrine mechanisms in testicular control. In: de Kretser DM (ed), Molecular Biology of the Male Reproductive System, pp 271-310. Academic Press, San Diego

E. Materials from a Website:

ATSDR (Agency for Toxic Substances and Disease Registry). 2000. Resources for information on asbestos and asbestos-related disease. Available at http://www.atsdr.cdc.gov/NEWS/asbestosinfo2.html

References Cited in Text: All references must be referred to in the text by author’s name and year of publication typed within parentheses (Voss and Fortune 1993), (Hall et al. 1997) or Kondo (1993). If there is more than one reference cited, they must be placed in chronological order within the parentheses (Kondo 1993; Hall et al. 1997) or USEPA (1999, 2000). If there is more than one reference cited with the same publication year, they must be alphabetized (Kondo 1993; Voss and Fortune 1993; Hall et al. 1997).

Tables: Tables should be used only when they can present information more effectively than running text. Care should be taken to avoid any arrangement that unduly increases the size of a table, and the column heads should be made as brief as possible, using abbreviations liberally. Lines of data must not be numbered unless those numbers are needed for reference in the text. Columns should not be used to contain only one or two entries, nor should the same entry be repeated numerous times consecutively. Titles should be typed above tables, using the format illustrated inside the parentheses (Table 1. Average body weight data for rats receiving biphenyl in their diet.).

Figures and Graphs: Figures and graphs should be furnished as tif, eps or jpg files with a minimum resolution of 500 dpi. Power Point, Excel, and embedded Word images are not acceptable.

Given that the journal is only published electronically, there are no additional charges for the publication of color images. Color reprints, however, will incur additional charges.

Reprints: Forms and instructions for ordering reprints will be available at the page proof stage of the review process. Reprints can also be ordered any time thereafter.