Title and Site for

International Hormesis Society’s

2004 Annual Conference

June 8 – 10, 2004
 

NON-LINEAR DOSE-RESPONSE RELATIONSHIPS IN BIOLOGY, TOXICOLOGY, AND MEDICINE 2004

Scientific Foundations for Pharmaceuticals and

Environmental Risk Assessment

University of Massachusetts, Amherst, MA US

Conference Coordinator
 

Denise Leonard, MSc

Registration Fees

Full Three Days: $399

Government and Academic Rate: $199

Student Rate: $99
 

Award Recipient for “Outstanding New Researcher in the Field of Hormesis”
 

Instituted in 2007

Award Recipient for “Outstanding Senior Researcher in the Field of Hormesis”
 

Instituted in 2007

Platform Presentation:
Plenary Session

Moderator: Paul T. Kostecki, Ph.D., Vice Provost for Research, University of Massachusetts, Amherst, MA

Temporal Hormesis Associated with Heart Failure and Animal Asthma Model
Richard A. Bond, University of Houston, Houston, TX
Zsuzsanna Callaerts-Vegh, University of Houston, Houston, TX

Reflections on Twenty Years in Risk Assessment: Lessons Learned and How They Relate to Incorporating Hormesis into the Paradigm
Dennis J. Paustenbach, ChemRisk, Inc.¨, San Francisco, CA

Relationship Between Toxicity and Hormesis in Rats Treated with Various Dioxins
Karl K. Rozman, Ph.D., University of Kansas Medical Center, Kansas City, KS
Margitta Lebofsky, University of Kansas Medical Center, Kansas City, KS
David M. Pinson, University of Kansas Medical Center, Kansas City, KS

Hormesis: Changing the Toxicological Paradigm
Edward J. Calabrese, University of Massachusetts, Amherst, MA
  

Platform Presentation:
Radiation

Moderator: Ron Mitchel, Atomic Energy Canada Limited, Chalk River,Ontario, Canada

Low Doses of Radiation are Protective in vitro and in vivo
Ron Mitchel, Atomic Energy of Canada Limited, Chalk River, ON, Canada

Non-Linear Response for Neoplastic Transformation following Low Doses of Low LET Radiation
J. Leslie Redpath, University of California Irvine, Irvine, CA

Low-Dose Radiation-Induced Protective Process and Implications for Risk Assessment, Cancer Prevention, and Cancer Therapy
Bobby R. Scott, Lovelace Respiratory Research Institute, Albuquerque, NM
Dale M. Walker, Lovelace Respiratory Research Institute, Albuquerque, NM

Update on the Department of Energy Low Dose Radiation Research Program
Noelle Metting, Sc.D., U.S. Department of Energy, Washington, D.C.

Biological Effects of Low Dose Radiation
Philippe Duport, University of Ottawa, Ottawa, Ontario, Canada

Low Dose Body Irradiation Prevention and Therapy of Cancer
Myron Pollycove, School of Medicine University of California San Francisco
  

Platform Presentation:
Biomedical

Moderator: Mark P. Mattson, Laboratory of Neurosciences, Baltimore, MD

Hormesis is a Mechanism Underlying Beneficial Effects of Dietary Restriction in Rodents
Mark P. Mattson, Ruiqian Wan, Zhihong Guo, Wenzhen Duan, National Institute on Aging Intramural Research Program, Baltimore, MD

Hormesis in Dose-Response Studies with Fungitoxins and Phytotoxins
Stephen O. Duke, USDA, ARS, University, MS, Albrecht Michel, Syngenta Crop Protection AG, Stein, Switzerland, Anna Oliva, State Univ. of New York, Stony Brook, NY, Regina G. Belz, Univ. Hohenheim, Stuttgart, Germany

Low Dose Effects in Psychopharmacology: Ontogenetic Considerations
Linda Patia Spear, Binghamton University, Binghamton, NY

Are Low Doses of DNA Damaging Agents Anti-Mutagenic?
Pamela J. Sykes, Sarah J. Swinburne, Flinders University and Medical Centre, Bedford Park, South Australia, Madhava Bhat, Royal Adelaide Hospital, Adelaide, SA, Australia, John Cormack, Tanya K Day, Flinders University and Medical Centre, Bedford Park, South Australia, Renate U Domel, William M. Burch, Australian Nuclear Science and Technology Organisation, Menai, New South Wales, Australia, Alexander A. Morley, Antony M. Hooker, Flinders University and Medical Centre, Bedford Park, South Australia

Stress Immunology: Differential Dose-Response
Jeffrey A. Woods, Ph.D., University of Illinois at Urbana-Champaign, Urbana IL
  

Platform Presentation:
Toxicology

Moderator: Raymond Yang, Colorado State University, Fort Collins, CO

Distinct Gene Expression Profiles in Lung Cells at Toxic vs Non-Toxic Nickel Doses
Robert Y.-S. Cheng, University of Massachusetts Medical School, Worcester, MA
W. Gregory Alvord, Data Management Services, Inc., Ft. Detrick, Frederick,
Lucy M. Anderson, National Cancer Institute at Frederick, Ft. Detrick, Frederick MD

Arsenic as an Endocrine Disruptor: Complex Dose Dependent Effects of Arsenic on Steroid Receptor Signaling
Josh Hamilton, Jack E. Bodwell, Dartmouth Medical School, Hanover, NH

Chemically Induced Liver Tumors and the Possibility of Hormesis
James Klaunig, Indiana University of Medicine, Indianapolis, IN

Chemical Mixtures: Nonlinear Dose-Response Phenomenon, Physiologically Based Pharmacokinetics, and Reaction Network Modeling
Raymond S. H. Yang, Colorado State University, Foothills Campus, Fort Collins, CO

The Non-Linear Nature of Lead-Related Changes in Behavior and Neurochemistry
Deborah A. Cory-Slechta, University of Medicine and Dentistry of New Jersey and Rutgers University, Piscataway, NJ

Universality of J-Shaped and U-Shaped Dose- Response Relations in Stochastic Transition Systems
Louis Anthony (Tony) Cox, Jr., Cox Associates and University of Colorado, Denver, CO 
  

Platform Presentation:
Regulatory/Risk Session

Moderator: Barbara Beck, Gradient Corp., Cambridge, MA

Implications of the Hormesis Response for Cancer Risk Assessment
Jonathan Borak, Yale University, New Haven, CT

The Search for Non-Linear Exposure-Response Relationships at Ambient Levels in Environmental Epidemiology
Morton Lippmann, New York University School of Medicine, Tuxedo, NY

Public Policy Implications of Hormesis
Joseph V. Rodricks, Ph.D., DABT, ENVIRON International Corporation, Arlington, VA

Some Implications of Nonlinear Dose-Response Relationships for Quantitative Risk Assessment
Robert L. Sielken Jr., Ph.D., Sielken & Associates Consulting, Inc., Bryan, TX

Precautionary Principles, Anticipatory Actions and Hormesis: Society Gains a New Regulatory Paradigm
Paolo F. Ricci, Thomas R. MacDonald, University of San Francisco and University of Queensland, San Francisco, CA 
   

Luncheon Speaker:
Robert Huggett
Vice President for Research and Graduate Studies, Michigan State University, East Lansing, MI 
 

Trends in Environmental Research from Canaries to Genomics

Luncheon Speaker:
Angela Eggelston
North American Editor of Nature
 

Through the Looking Glass: An Editorial Perspective on Publishing

Conference Scientific
Advisory Board

Iris Bell, M.D., Ph.D., The University of Arizona College of Medicine

Michael P. Bolger, Ph.D., US FDA

Richard Bond, Ph.D., University of Houston

Giovanni Carelli, Ph.D., Catholic University of Sacred Heart, Italy

Peter M. Chapman, Ph.D., EVS Environmental Consultants, Ltd., Canada

David M. Diamond, Ph.D., University of South Florida

Ludwig E. Feinendegen, M.D., Heinrich-Heine-University, D.sseldorf, Germany

Donald E. Gardner, Ph.D., Inhalation Toxicology Association

John H. Graham, Ph.D., Berry College, Dept of Biology

A. Wallace Hayes, Ph.D., The Gillette Company

Wayne Jonas, M.D., USUHS

Ralph L. Kodell, Ph.D., NCTR

Walter J. Kozumbo, Ph.D., AFOSR/NL

Shu-Zheng Liu, M.D., MH Radiobiology Research Unit

Werner K. Lutz, Ph.D., University of Wuerzburg, Germany

Harihara M. Mehendale, Ph.D., DABT, Northeast Louisiana University

James B. Muckerheide, Director, Center for Nuclear Technology and Society at WPI

Ricardo Ochoa, Ph.D., Pfizer

James T. Oris, Ph.D., Miami University

Wim Passchier, Ph.D., Health Council of the Netherlands

Suresh I.S. Rattan, Ph.D., D.Sc., University of Aarhus, Denmark

George M. Rusch, Ph.D., Honeywell International

Kenneth R. Still, Ph.D., MBA, Naval Health Research Center/TD

Elmer Szabadi, Ph.D., Queen’s Medical Center, Div of Psychiatry, UK

Bailus Walker, Jr., Ph.D., M.P.H., Howard University College of Medicine

Richard Wilson, Ph.D., Harvard University

Raymond Yang, Ph.D., Colorado State University

Nasser H. Zawia, Ph.D., University of Rhode Island

Ed Zillioux, Ph.D., FPL Environmental Services
  

Poster Sessions

An Overview of the Hormesis Database
Robyn B. Blain, Edward J. Calabrese, University of Massachusetts, Environmental Health Sciences, Amherst, MA

Low-Dose Radiation and Diabetes
Lu Cai, Departments of Medicine, Pharmacology & Toxicology, University of Louisville School of Medicine, Louisville, KY and Department of Toxicology, Jilin University School of Preventive Medicine, Jilin PR China

Non-Linear Effect of Radiation on Erythrocyte Immunity
Guangjun Wang, Department of Hematology & Oncology, The First Hospital, Jilin University School of Medicine, Jilin, PR China, Lu Cai, Departments of Medicine, Pharmacology & Toxicology, University of Louisville School of Medicine, Louisville, KY and Department of Toxicology, Jilin University School of Preventive Medicine, Jilin PR China

Detecting Causal Nonlinear Exposure-Response Relations in Epidemiological Data
Louis Anthony (Tony) Cox, Jr., Cox Associates and University of Colorado, Denver, CO

Low-Dose Nonlinearity of Hematopoietic Dose-Response Relations
Louis Anthony (Tony) Cox, Jr., Cox Associates and University of Colorado, Denver, CO

Biphasic Dose-response Relationships in Human Experimental Exposure to Solvents
Ivo Iavicoli , Catholic University of Sacred Heart, Institute of Occupational Health, Rome, Italy, Giovanni Carelli, Catholic University of Sacred Heart, Institute of Occupational Health, Rome, Italy

Regulation of Glutathione by Oxidative Stress in Bovine Pulmonary Artery Endothelial Cell
Regina M. Day, Ph.D, Departments of Medicine and Pharmacology, Georgetown University Medical School, Washington DC, Yuichiro J. Suzuki, Ph.D., Department of Pharmacology, Georgetown University Medical School , Washington DC, Barry L. Fanburg, M.D., Department of Medicine, Tufts-New England Medical Center, Tupper Research Institute, Boston, MA

Effects of a Chronic Exposure to Lead Acetate on Immune Function in Swiss Mice
Ivo Iavicoli , Catholic University of Sacred Heart, Institute of Occupational Health, Rome, Italy, Giovanni Carelli, Catholic University of Sacred Heart, Institute of Occupational Health, Rome, Italy

Low Doses of Phenolic Compound Can Be Useful in Quick Recognition their Affinity to Laccase
Elzbieta Malarczyk, Janina Kochmanska-Rdest, Anna Jarosz-Wilkolazka, Maria Curie-
Sklodowska University, Biochemistry Department, Lubin, Poland

Regulation of Veratrate Demethylation in Rhodococcus erythropolis Cells by Low Doses of Formaldehyde
Elzbieta Malarczyk, Marzanna Pazdzioch-Czochra, Janina Kochmanska-Rdest, Maria Curie-Sklodowska University, Biochemistry Department, Lubin, Poland

Thimerosal for the Treatment of Influenza and Herpes Virus Infections
John McMichael, The Institute for Therapeutic Discovery, Delanson, NY
Allan D. Lieberman, Center for Occupational and Environmental Medicine, North Charleston, SC

Adaptive Immune Responses to Long-Term Low-Level Radiation Exposure: Feasibility Study on Dog Material from Argonne
Viktor Meineke, Kerstin M.ller, Karin M. Greulich-Bode, Dirk van Beuningen, Institute of Radiobiology, German Armed Forces, Munich, Germany, Thomas E. Fritz, Naperville, Illinois, Theodor M. Fliedner, Radiation Medicine Research Group and WHO Collaborating Center for Radiation Accident Management, University of Ulm, Helmholtzstrasse, Germany, Ludwig E. Feinendegen, Lindau, Germany

Cardiorenal Dose Response Relationship of Cadmium
V.N.Puri, S.Saha, Division of Pharmacology, Central Drug Research Institute, Lucknow, India

A Comparative Study of Drug Standardization in Hormetic Observations and Homeopathic Provings
Jahangir Satti, Ph.D., Department of Radiation Physics, St. Joseph's Medical Center, Stockton, CA

Complementary Nano-Scale Therapeutic Approach through Frequency Based Bio-Synchronization.
Jahangir Satti, Ph.D., Department of Radiation Physics, St. Joseph's Medical Center, Stockton, CA

Alcoholic Beverage Hormesis for Cataract and Atherosclerosis is Related to Plasma Oxidative Condition
Claire D. Prickett, Erin Lister, B.Sc., Michelle Collins, Colleen Trevithick-Sutton, B.Sc.,
Maurice Hirst, Ph.D., Earl Noble, Ph.D., University of Western Ontario, London, Ontario, Canada
Joe A. Vinson, Ph.D., University of Scranton, Scranton, PA
John R. Trevithick, Ph.D., University of Western Ontario, London, Ontario, Canada
 

Conference Sponsors

Air Force

Awwa Research Foundation

British American Tobacco

Department of Energy

ExxonMobil

Gradient Corporation

Health Canada

Honeywell International Inc.

Lorillard

NIPERA

Philip Morris, Inc.

Rhom and Haas Company

R. J. Reynolds

Samueli Institute for Information Biology

The Jerry Cohen Foundation