Title and Site for

International Hormesis Society’s

2003 Annual Conference

May 28 - 30, 2003
 

NON-LINEAR DOSE-RESPONSE RELATIONSHIPS IN BIOLOGY, TOXICOLOGY, AND MEDICINE 2003

Scientific Foundations for Pharmaceuticals and

Environmental Risk Assessment

University of Massachusetts, Amherst, MA US

Conference Coordinator
 

Denise Leonard, MSc

Registration Fees

Full Three Days: $399

Government and Academic Rate: $199

Student Rate: $99
 

Award Recipient for “Outstanding New Researcher in the Field of Hormesis”
 

Instituted in 2007

Award Recipient for “Outstanding Senior Researcher in the Field of Hormesis”
 

Instituted in 2007

Platform Presentation:
General Principles

Moderator: Russell Keenan, AMEC, Portland, ME

Biomedical Implications of Hormesis
Edward J. Calabrese, University of Massachusetts, Amherst, MA

Biological Switching Mechanisms and Dose Response Relationships
Melvin Andersen, CIIT-Center for Health Research, Research Triangle Park, NC

The Bystander Effect: Recent Developments and Implications for Understanding the Dose-Response
Ronald Mitchel, Atomic Energy of Canada, Ltd., Chalk River, ON

The Potential Impact of Hormesis on Risk Assessment
Russell Keenan, AMEC, Portland, ME

The Implications of Non-Linear Effects in Risk Assessment Harmonization
John A. Bukowski & R. Jeffrey Lewis, ExxonMobil Biomedical Sciences, Inc., Annandale, NJ

Economic Implications of Hormesis
Jim Hammit, Harvard University School of Public Health, Boston, MA
  

Platform Presentation:
Radiation

Moderator: Ludwig E. Feinendegen, Heinrich-Heine-University D.sseldorf, Germany

Assessment of Low-Dose Radiation Risk in Europe: Diverging Authorities and Scientists
Klaus Becker, Radiation, Science & Health, Berlin, Germany

Responses to Low Doses of Ionizing Radiation in Biological Systems
Ludwig E. Feinendegen, Heinrich-Heine-University D.sseldorf, Germany
Myron Pollycove, University of California San Francisco Medical School, San Francisco, CA

Radiation-Induced Change in Cell Proliferation and its Neuroendocrine Regulation: Dose-Response Relationship and Pathophysiological Implications
Shu-Zheng Liu, MH Radiobiology Research Unit, Jilin University Health Sciences Center, Changchun, China

Low-Dose Radiation and Genotoxic Chemicals Protect Against Stochastic Biological Effects
Bobby R. Scott, Dale M. Walker & Vernon Walker, Lovelace Respiratory Research Institute, Albuquerque, NM

Low Dose Radiation Health and Medical Benefits: A Century of Hard Data and Soft Science
Jim Muckerheide, Center for Nuclear Technology and Society, Worcester Polytechnic Institute, Worcester, MA
  

Platform Presentation:
Chemical Carcinogenesis

Moderator: Ludwig E. Feinendegen, Heinrich-Heine-University D.sseldorf, Germany

Dose-Response Curves in Chemical Carcinogenesis
William J. Waddell, University of Louisville, Dept. of Pharmacology and Toxicology, Prospect, KY

Detoxication Strategy of Epoxide HydrolaseÐThe Basis for a Novel Threshold for Definable Genotoxic Carcinogens
Franz Oesch & Michael Arand, Institute of Toxicology, University of Mainz, Mainz, Germany
  

Platform Presentation:
Biochemical

Moderator: Wayne Jonas, Samueli Institute, Bethesda, MD

The Treatment of Chronic Prostatitis with Low Level Chorionic Gonadotropin
John McLane & John McMichael, Milkhaus Laboratory, Inc., Providence, RI

Non-Linear Dose-Response Effects of Neurosteroids on Brain Plasticity and Memory
David M. Diamond, University of South Florida and Veterans Hospital, Tampa, FL

Possible Clinical Implications of Hormesis
Wayne Jonas, Samueli Institute, Bethesda, MD

Biphasic and U-Shaped Opioid Dose-Responses in the Immune System
Burt M. Sharp, University of Tennessee, Memphis, TN

Molecular Mechanisms of Anti-Aging Effects of Mild Heat Stress on Human Cells
Dr. Suresh I.S. Rattan, University of Aarhus, Denmark

Biphasic Response of Ciprofloxacin in Human Fibroblast Cell Cultures
Filiz Hincal & Aylin G.rbay, University of Hacettepe, Ankara, Turkey
Alain Favier, Universite Joseph Fourier, France
 

Platform Presentation:
High Profile Toxic Substances and the Non-Linear Features of their Dose-Response Relationships

Moderator: Ralph L. Kodell, U.S. Food and Drug Administration, Jefferson, AR

Asbestos: Non-Linear Dose Response Relationships in in vitro Assays and Inhalation Experiments
Brooke Mossman & Arti Shukla, Ph.D., University of Vermont College of Medicine, Burlington, VT, Pamela Vacek, PhD,University of Vermont, Burlington, VT

The Particulate Air Pollution Controversy
Robert F. Phalen, University of California, Irvine, CA

Mechanistic Model Predicts Low-Dose Nonlinearity of Liver Tumor Risk in Mice Fed Fumonisin B1
Ralph L. Kodell & Angelo Turturro, U.S. Food and Drug Administration, Jefferson, AR

Dioxin
Thomas Starr, TBS Associates, Raleigh, NC

The Chloroform Saga: Science Trumps Policy?
Jay Goodman, Michigan State University, East Lansing, MI

Justification, Application and Implication of Presumed Linearity for Dioxin and Dioxin-Like Compounds
John D. Schell, BBL Sciences, Tallahassee, FL

Non-Linear Dose-Response Relationships in Endocrine Disruption
John Ashby, Syngenta Central Toxicology Lab, Cheshire, UK
  

Platform Presentation:
Toxicology

Moderator: Louis Anthony Cox, Jr., Cox Associates and University of Colorado, Denver, CO

Nonlinearity in the IQ-Blood Lead Relation: Redefining Low Level Exposure
Richard L. Canfield, Cornell Univeristy, Ithaca, NY
Todd A. Jusko, University of Washington, Seattle, WA
Charles R. Henderson, Jr., Cornell University, Ithica, NY

Non-Linear Dose-Response Relationships in Experimental Neurotoxicology
Victor W. Pentreath, University of Salford, Salford, U.K.

Nonlinear Low-dose Hematotoxicity
Louis Anthony Cox, Jr., Cox Associates and University of Colorado, Denver, CO
 

Platform Presentation:
Regulatory Forum on Non-Linear Dose-Response

Moderator:
Myron Harrison, ExxonMobil Corporation, Irving, TX
Chris DeRosa, ATSDR, Atlanta, GA
James Muckerheide, Radiation Science and Health, Needham, MA
Michael Bolger, FDA, Washington, DC
Matt Bogdanffy, Dupont, Newark, DE
Scott Stoner, Department of Environmental Conservation, Albany, NY
 

Luncheon Speaker:

Dr. Joseph Borzelleca
Medical College of Virginia, Richmond, VA
 

You Have a Brain in Your Head, Feet in Your Shoes,
Steer Yourself Any Direction You Choose (Dr. Seuss)

Luncheon Speaker:

Philip G. Lewis, MD

Vice President, Rohm and

Haas Company, Bristol, PA
 

Why the Company Whose Stock You Own Doesn’t Care About Risk Assessment

Conference Scientific
Advisory Board

Iris Bell, M.D., Ph.D., The University of Arizona College of Medicine

Michael P. Bolger, Ph.D., US FDA

Richard Bond, Ph.D., University of Houston

Giovanni Carelli, Ph.D., Catholic University of Sacred Heart, Italy

Peter M. Chapman, Ph.D., EVS Environmental Consultants, Ltd., Canada

David M. Diamond, Ph.D., University of South Florida

Ludwig E. Feinendegen, M.D., Heinrich-Heine-University, D.sseldorf, Germany

Donald E. Gardner, Ph.D., Inhalation Toxicology Association

John H. Graham, Ph.D., Berry College, Dept of Biology

A. Wallace Hayes, Ph.D., The Gillette Company

Michael Jayjock, Ph.D., Rohm & Haas

Wayne Jonas, M.D., USUHS

Ralph L. Kodell, Ph.D., NCTR

Walter J. Kozumbo, Ph.D., AFOSR/NL

Shu-Zheng Liu, M.D., MH Radiobiology Research Unit

Werner K. Lutz, Ph.D., University of Wuerzburg, Germany

Harihara M. Mehendale, Ph.D., DABT, Northeast Louisiana University

James B. Muckerheide, Director, Center for Nuclear Technology and Society at WPI

Ricardo Ochoa, Ph.D., Pfizer

James T. Oris, Ph.D., Miami University

Wim Passchier, Ph.D., Health Council of the Netherlands

Suresh I.S. Rattan, Ph.D., D.Sc., University of Aarhus, Denmark

Denise Robinson, Ph.D., Pfizer

George M. Rusch, Ph.D., Honeywell International

Leslie Stayner, Ph.D., NIOSH

Elmer Szabadi, Ph.D., Queen’s Medical Center, Div of Psychiatry, UK

Bailus Walker, Jr., Ph.D., M.P.H., Howard University College of Medicine

Richard Wilson, Ph.D., Harvard University

Raymond Yang, Ph.D., Colorado State University

Nasser H. Zawia, Ph.D., University of Rhode Island

Ed Zillioux, Ph.D., FPL Environmental Services
 

Poster Sessions

The Influence of Lead and Mercury on Beta-Amyloid Aggregation and Cytotoxicity
M.D. Basha, W. Wei & N.H. Zawia, University of Rhode Island, Kingston, RI

Effect of Hydroperoxide and Water Specimens of Different Composition and Physicochemical Properties on the Structure of Membranes and Activity of Membrane Enzymes
Elena B. Burlakova, Alexander N. Goloshchapov, Elena M. Molochkina & Lyudmila D. Fatkhulina, Emanuel Institute of Biochemical Physics, Moscow, Russia

Metallothionein as an Adaptive Protein Prevents Diabetes and its Toxicity
Lu Cai, Department of Medicine, University of Louisville, KY

Hormesis at NTP: Evidence of Hormetic Dose Responses in NTP Dose-Range Studies
Edward J. Calabrese & Linda A. Baldwin, University of Massachusetts, Amherst, MA

Effects of Low-Dose Exposures to X-rays on the Non-Specific Anti-Tumor Responses in Mice
Aneta Cheda, Jolanta Wrembel-Wargocka, Emil Lisiak, Ewa Nowosielska, Maria Marciniak & Marek K. Janiak, Military Institute of Hygiene and Epidemiology, Warsaw, Poland

Experimental Study of Subchronic Toxicity of Lanthanum Nitrate on Liver in Rats
Dong Chen, Ying Liu & Yu-Xiu Nie, Jilin University, Changchun, Jilin, PR China

The Immune Effects of Radiation Observed from the Incident of Co-60 Contaminated Apartments in Taiwan
W.L. Chen, Y.C. Luan, S.H. Mong, J.T. Wu, C.P. Sun & H.Y. Shen, Nuclear Science & Technology Association, Taipei, Taiwan, ROC, M.C. Shieh, T.S. Chou, S.T. Chen, K.L Soong, Y.C. Yeh & W.K. Wang, Nuclear, Biological and Chemical Protection Society, Taipei,Taiwan, ROC, C.M. Tsai, Atomic Technology Foundation, Taipei, Taiwan , ROC, M.L. Shen, National Taiwan University, Taipei, Taiwan, ROC

Health Risks from Fluoridated Water
Myron J. Coplan, Intellequity Technology Services, Natick, MA

Secondary Ultraweak Luminescence from Humic Acids Induced by Gamma Radiation
Wieslaw Goraczko & Janusz Slawinski, Poznan University of Technology, Poznan, Poland

Non-Linear Dose Response Relationships in the Definition of Occupational Exposure Limits
Ivo Iavicoli & Giovanni Carelli, Institute of Occupational Health, Universit. Cattolica del Sacro Cuore, Roma, Italy

Heterogeneous Exposure Dose Levels Unable to Induce Harmful Effects of Life Expectancy and Blastomogenesis
Valentina S. Kalistratova, Lev A. Buldakov, Petr G. Nisimov & Irina B. Romanova, State Research Center of Russia, Moscow, Russia

Alcohol and Blood Pressure: a Complex Nonlinear Relationship
Arthur L. Klatsky, MD, Kaiser Permanente Medical Center, Oakland, CA
Natalia V. Udaltsova, PhD, Kaiser Permanente Division of Research, Oakland CA

Stress Response and Cellular Longevity: The Prolonged Lifespan of Cushingâs-Syndrome-Patientsâ Fibroblasts
Dimitris Kletsas, Harris Pratsinis, Irene Zervolea & Dimitri Stathakos, National Centre for Scientific Research ÒDemokritosÓ, Athens, Greece, Fivos Giannakopoulos, Nikos Thalassinos & Stylianos Tsagarakis, Evangelismos Hospital, Athens, Greece

Hormetic Effects at Clinical Levels
Marios Kyriazis MD, British Longevity Society, Hemel Hemsptead, UK

SynergyÐThe Effect of Combining Non-Linear Dose Profiles: The Prediction and Quantification of the Potentiation of EDTA with Antimicrobials
R. J. W. Lambert, R2-Scientific,Sharnbrook, Beds, UK
Stephen P. Denyer & Geoff W. Hanlon, University of Brighton, Brighton, UK

Effect of Single WBI with Low Doses of X-rays on the Development of and Blood Supply to the Pulmonary Tumor Colonies in Mice
Emil Lisiak, Military Institute of Hygiene and Epidemiology, Warsaw, Poland
Miroslaw Dziekiewicz, Clinical Hospital of Military Medical University, Warsaw, Poland
Krzysztof W. Zielinski, Military Medical University, Lodz, Poland
Aneta Cheda, Military Institute of Hygiene and Epidemiology, Warsaw, Poland
Jolanta Wrembel-Wargocka, Military Institute of Hygiene and Epidemiology, Warsaw, Poland
Sebastian Dominiak, Military Medical University, Lodz, Poland
Marek K. Janiak, Military Institute of Hygiene and Epidemiology, Warsaw, Poland

Effect of Low and Very Low Doses of Simple Phenolics on Plant Peroxidase Activity
Elzbieta Malarczyk, Janina Kochmanska-Rdest & Marzanna Pazdzioch-Czochra, Maria Curie-Sklodowska University, Lublin, Poland

The Use of Streptolysin O for the Treatment of Scars, Adhesions and Fibrosis
Stephen W. Mamber, Vit Long, Ryan G. Rhodes, Sunthorn Pond-Tor, Lyn R. Wheeler, Kellie Fredericks, Brian Vanscoy, Jean-Frederic Sauniere & John McMichael, Milkhaus Laboratory Inc., Providence, RI Remy Steinschneider & Jean-Claude Laurent, Bio Expertise Technologies, Marseille, France

Comparison in vivo Study of Genotoxic Action of High versus Very Low Dose-Rate g-Irradiation
Andreyan N. Osipov, Moscow SIA ÒRadonÓ, Moscow, Russia
Dmitry Yu. Klokov, Institute of Theoretical and Experimental Biophysics, Moscow Region, Russia
Alexander L. Elakov, Moscow SIA ÒRadonÓ, Moscow, Russia
Olga M. Rozanova & Svetlana I. Zaichkina, Institute of Theoretical and Experimental Biophysics, Moscow Region, Russia

The Use of Low Dose Thimerosal for the Treatment of Herpesvirus Infections
Sunthorn Pond-Tor, Ryan G. Rhodes, Albert E. Dahlberg & John McMichael, Milkhaus Laboratory, Inc., Providence, RI

Effect of Low Dose of Cadmium on Transformation of Normal Human Prostate Cells
N.V. Rajeshkumar, Jaya P. Gaddipati, Jason C. Grove & Radha K. Maheshwari, Uniformed Services University of the Health Sciences, Bethesda, MD
Wayne B. Jonas, Samueli Institute for Information Biology, Alexandria, VA

Hormetic Modulation of Aging and Longevity in Fruitflies
Dr. Suraj P. Sharma, Guru Nanak Dev University, Amritsar, India
Dr. Suresh I.S. Rattan, University of Aarhus, Aarhus, Denmark

Particulate Matter (PM) Increments may not be Causal in Mortality and Morbidity
Peter A. Valberg, Gradient Corporation, Cambridge, MA

Epidemiological Evaluation of the Threshold Model for Hexavalent Chromium
Edwin van Wijngaarden, Rose S. Luippold & Kenneth A. Mundt, PhD, Applied Epidemiology, Inc., Amherst, MA

Hematopoietic Hormesis and Adaptive Response Induced by LDR is Likely Due to Up-Regulation of Hematopoiesis-related Cytokines
Guangjun Wang, The First Hospital of Jilin University, PR China
Lu Cai, The First Hospital of Jilin University, PR China and University of Louisville, KY

The APP Promoter Responds to Pb Exposure in Transfected PC12 Cells
W. Wei, M.D. Basha & N.H. Zawia, University of Rhode Island, Kingston, RI

Low Doses Gamma-Radiation Induce Non-Linear Dose Response in Mammalian and Plant Cells
Svetlana I. Zaichkina, Olga M. Rozanova, Gella F. Aptikaeva, Asia Ch. Achmadieva &
D. Ju Klokov, Institute of Theoretical and Experimental Biophysics, Moscow Region, Russia

Effect of Mixed Rare Earth Changle Crossing Placenta Membrane on Embryo Cell DNA Damage
Li Zhou, Li Shulei & Nie Yuxiu, Jilin University, Changchun, Jilin Province, PR China
  

Conference Sponsors

Air Force

CRC Press

Department of Energy

ExxonMobil

Gradient Corporation

Health Canada

Honeywell

Lorillard

NIPERA

Philip Morris, Inc.

Radiation Science and Health Center for Nuclear Technology and Society at WPI

Rhom and Haas Company

R. J. Reynolds

Samueli Institute for Information Biology

The Jerry Cohen Foundation