Title and Site for

International Hormesis Society’s

2002 Annual Conference

June 11 – 13, 2002
 

NON-LINEAR DOSE-RESPONSE RELATIONSHIPS IN BIOLOGY, TOXICOLOGY, AND MEDICINE 2002

Scientific Foundations for Pharmaceuticals and

Environmental Risk Assessment

University of Massachusetts, Amherst, MA US

Conference Coordinator
 

Denise Leonard, MSc

Registration Fees

Full Three Days: $399

Government and Academic Rate: $199

Student Rate: $99
 

Award Recipient for “Outstanding New Researcher in the Field of Hormesis”
 

Instituted in 2007

Award Recipient for “Outstanding Senior Researcher in the Field of Hormesis”
 

Instituted in 2007

Platform Presentation:
Plenary

Moderator: Paul T. Kostecki, University of Massachusetts, Amherst, MA

Biphasic Dose Responses in the Biological Sciences
Edward J. Calabrese, University of Massachusetts, Amherst, MA

Implications of Non-Linearity for Ecotoxicological Risk Assessment
Keith Solomon, University of Guelph, Guelph, Ontario, Canada

Evolutionary Foundations of Non-Linearity
Lorenz Rhomberg, Gradient Corporation, Cambridge, MA

Risk Assessment Implications of Non-Linear Dose-Responses
William F. Greenlee, Chemical Industry Institute of Toxicology, Research Triangle Park, NC; Frederick J. Miller, CIIT Centers for Health Research, Research Triangle Park,NC; Rory B. Conolly, Center for Computational Biology & Extrapolation Modeling, Research Triangle Park, NC
 

Platform Presentation:
Chemical

Moderator: John DeSesso, Mitretek Systems, Inc., Falls Church, VA

Complex Shapes of Dose-Response Curves as the Summation of Underlying Low-Dose-Linear and Saturable Processes
Rory Conolly, CIIT Centers for Health Research, Research Triangle Park, NC
David W. Gaylor, Sciences International, Inc., Little Rock, AR
Kevin W. Gaido, CIIT Centers for Health Research, Research Triangle Park, NC
Werner K. Lutz, University of Wurzburg, Wurzburg

From Mice to Men, Cancers Are Not Certain at Old Age
Francesco Pompei & Richard Wilson, Harvard University, Cambridge, MA

Implications of Hormesis in Developmental Toxicology Risk Assessment
Mehdi Razzaghi, Bloomsburg University, Bloomsburg, PA

Using Dose and Time to Predict Acute and Chronic Toxicity
Karl Rozman, University of Kansas Medical Center, Kansas City, KS

Experiences with Non-Linear Dose-Response Relationships in Chemical Evaluations
Dennis Jones, ATSDR, Atlanta, GA

Risk Modeling Implications of Mechanistic Differences between Low and High Dose Effects of Arsenic
Christopher Wells,Tracey M. Slayton, Barbara C. Beck & Thomas A. Lewandowski, Gradient Corporation, Cambridge, MA

Hormesis, Low Dose Carcinogenicity and Low Dose Anti-Carcinogenicity Occur in the Same Animal and with the Same Chemical
Richard Wilson, Harvard University, Cambridge, MA

Data for Trichloroethylene-Induced Kidney Tumors in Rodents Suggest an Epigenetic Mechanism of Action
Amy Lavin, International Life Sciences Institute, Washington, DC
Catherine F. Jacobson & John M. DeSesso, Mitretek Systems, Inc., Falls Church, VA

Quantitation of the Dose Response for Formation of DNA Adducts in Rat Liver by 2-Acetylaminofluorene
Gary Williams, Michael J. Iatropolous, Jian-Dong Duan & Alan M. Jeffrey, New York Medical College, Valhalla, NY
 

Platform Presentation:
Radiation

Moderator: Klaus Becker, Berlin, Germany

Impact of Cellular Defense Mechanisms and Bystander Effects on a Multi-Stage Carcinogenesis Model
Helmut Schollnberger, University of Salzburg, Salsburg, Austria/Europe;
Margaret G. Menache, University of New Mexico, Albuquerque, NM; Rod
Stewart, Pacific Northwest National Laboratory (PNNL), Richland, WA;
Werner Hofmann, University of Salzburg, Salsburg, Austria/Europe

Human Cells Respond to Changes in Background Radiation by Inducing Specific Heat Shock Protein Members
Satya P. Saxena, Neerad C. Mishra, & Steven P. Allen, Lovelace Respiratory
Research Institute, Albuquerque, NM; Raymond A. Guilmette, Los Alamos National Laboratory, Los Alamos, NM

Low-Dose Protective Mechanisms: Implications for Risk Assessment
Bobby R. Scott, Dale M. Walker, Vernon Walker, James Aden, & Yohannes Tesfaigzi, Lovelace Respiratory Research Institute, Albuquerque, NM

Non-Linear Dose-Response Curves in the Immune System Following Whole-Body X-Irradiation
Shu-Zheng Liu, Norman Bethune University of Medical Sciences, Changchun, China

The Hormetic Health Effects of Radiation Observed in the Incident of Co-60 Contaminated Apartments in Taiwan
Y.C. Luan, M.C. Shieh, S.T. Chen, K.L. Soong, & W.K. Wang, Nuclear Science & Technology Association, Taipei, Taiwan, ROC; C.M. Tsai, Atomic Technology Foundation, Taipei, Taiwan, ROC; W.L. Chen, T.S Chou, S.H. Mong, J.T. Wu & C.P. Sun, NBC Protection Society, Taipei, Taiwan, ROC

Dose-Response Relationship: Chromosome Aberrations in Residents at the High Background Radiation Areas in Ramsar, Iran
S.M. Javad Mortazavi & Takaji Ikushima, Kyoto University of Education, Kyoto, Japan;
P. Andrew Karam, University of Rochester, Rochester, NY

Residential Radon in U.S. Counties vs. Lung Cancer in Women who Predominantly Never Smoked
K.T. Bogen, Lawrence Livermore National Laboratory, Livermore, CA;
J. Cullen, University of California Berkeley, Berkeley, CA

Treatment of Confounding Factors in Ecological Study Test of Linear-No Threshold Theory
Bernard Cohen, University of Pittsburgh, Pittsburgh, PA

The Bolton-Brush Radiographic Growth Studies
B. Holly Broadbent & P.S. Rao, Case Western Reserve University, Cleveland, OH
 

Platform Presentation:
Ultra-Low Doses and Medicine

Moderator: Wayne Jonas, Samueli Institute, Alexandria, VA

Effects of Low Dose Cadmium on Stress Proteins and Survival in Human Prostate Cells
Jaya Gaddipati, Rajesh Kumar NV, Uniformed Services University of the Health Sciences, Bethesda, MD; William Achanzar, NCI at NIEHS,Research Triangle Park, NC; Radha K. Maheshwari, Wayne Jonas, Uniformed Services University of the Health Sciences, Bethesda, MD

Non-Immunological Sensitization: A Nonlinear Host Dose-Response to Repeated Low Level Chemical Exposures
Iris Bell, The University of Arizona College of Medicine, Tucson, AZ;
Carol Baldwin, Gary E. Schwartz, University of Arizona, Tuscon, AZ

Ultra-low Doses and Biological Responses: A Review of the Literature and Recent Experiments
Wayne B. Jonas, Samueli Institute, Alexandria, VA

High Sensitivity 1H-NMR Studies of Homeopathic Remedies: Unexplained Peaks in the Spectra of Some Samples
David Anick, Harvard University, Cambridge, MA

Challenges to the Investigation of Low and Ultra-Low Dose Effects
Roeland van Wijk, University of Utrecht, Geldermalsen, The Netherlands

Low Dose Effects in Pulmonary Disease
Rebecca Bascom, Penn State Milton S. Hershey Medical Center, Hershey, PA
 

Platform Presentation:
Biomedical

Moderator: David Diamond, University of South Florida, Tampa, FL

Non-Linear Functions between Stress Hormones, Brain Plasticity and Memory
David Diamond, University of South Florida, Tampa, FL

Biphasic Effects of Progesterone Treatment on Proliferation of Normal and Malignant Human Ovarian Surface Epithelial Cells
Viqar Syed & Shuk-Mei Ho, University of Massachusetts Medical School, Worcester, MA

Two Examples of Paradoxical Pharmacology Using In Vivo Animal Models of Disease
Kenda LJ Evans, Zsuzsanna Callaerts-Vegh, University of Houston, Houston, TX;
Felix Shardonofsky, Texas Children’s Hospital, Houston, TX;
Heather Giles, GlaxoSmithKline, Herfordshire, UK;
Richard Bond, University of Houston, Houston, TX

Using C. elegans to Model Induced Stress Resistance and Life Span Hormesis
James Cypser & Thomas E. Johnson, University of Colorado, Boulder, CO.

Biological Aging and Its Hormetic Modulation by Repeated Challenge
Suresh Rattan, University of Aarhus, Aarhus, Denmark

Hormetic vs Inhibitory Effects in Sea Urchin Bioassays
Giovanni Pagano, Istituto Nazionale Tumori, Naples, Italy

Non Linear Factors Affecting Exposure and Risk to Anthrax
Dennis Jones, ATSDR, Atlanta, GA

Biphasic Effects of Cardiac Glycosides (Ouabain) on Vascular Smooth Muscle Cell Proliferation
Julius Allen, Joel Abramowitz & Ashihan Aydemir-Koksoy, Baylor College of Medicine, Houston, TX

Altered Phenotype in Glial Cells Underlies the Low-Dose Neuroprotection Against Neurotoxicity
Victor M. Pentreath, University of Salford, Salford, UK;
Mark R. Cookson, Mayo Clinic, Jacksonville, FL; Carole Mead, Christie Hospital, Manchester, UK; Debbie Slamon, AstraZeneca Pharmaceuticals, Cheshire, UK

Is the Hygiene Hypothesis an Example of Hormesis?
John A. Bukowski, ExxonMobil Biomedical Sciences, Inc., Annandale, NJ;
Philip G. Lewis, Rohm and Haas Company, Bristol, PA

Tissue-Specific Dysfunction Induced by Menadione in Blood Vessels: Mechanisms for U-shape Dose-Response Curve
Jin-Ho Chung & Jee-Yeon Han, Seoul National University, Soeul, Korea
 

Platform Presentation:
Risk Assessment

Moderator: Gary Marchant, Arizona State University, Tempe, AZ

Non-Linear Dose Response: Legal Standards for the Admission of Novel Scientific Theories in Regulatory Decision-Making
Gary Marchant, Arizona State University College of Law, Tempe, AZ

Implications of Hormesis for Industrial Hygiene
Michael Jayjock, Rohm and Haas Company, Spring House, PA;
Philip G. Lewis, Rohm and Haas Company, Bristol, PA

Do We Need any Legal Limits for Radon below about 500 Bq/m3?
Klaus Becker, Berlin, Germany

Some Thoughts about How to Incorporate Hormesis Into the Risk Assessment Process
Brent L. Finley, Exponent, Santa Rosa, CA;
Dennis J. Paustenbach, Exponent, Menlo Park, CA

Radiation Hormesis: Molecular-Cellular Biology, Epidemiology, and Prevention and Therapy of Cancer
Myron Pollycove, University of California, North Bethesda, MD;
Ludwig E. Feinendegen, Heinrich-Heine-University Duesseldorf, Lindau, Germany

Basic Research Needs Panel (DOE, NIEHS, CIIT, Air Force, Pharmaceutical Industry)
Kenneth A. Mundt, Applied Epidemiology, Inc., Amherst, MA
Wayne Jonas, USUHS, Bethesda, MD, Klaus Becker, Berlin, Germany
Antone L. Brooks, Washington State University, Richland, WA
Rory B. Conolly, Center for Computational Biology & Extrapolation Modeling, Research Triangle Park, NC
 

Luncheon Speaker:

Joscelyn Kaiser

Science News Reporter, Science
 

Reporting on Toxicology and Risk Assessment

Luncheon Speaker:

John Doull, M.D., Ph.D.

Dept of Pharmacy, Toxicology and Therapeutics, University of Kansas Medical Center
 

Risk Assessment Milestones

Poster Sessions

Neurobehavioral Hormesis: The Exclusion of Compounds that Activate Arousal Systems in the Brain
Marni Y.V. Bekkedal, Glenn D. Ritchie, Kenneth R. Still & John Rossi III, Naval Health
Research Center Detachment (Toxicology), Wright-Patterson Air Force Base, OH

Debates Over Linearity: Much Ado About Evidence; Not Enough About Relevance Nor Preference
Kevin P. Brand, University of Ottawa, Ottawa, ON, Canada;
Lorenz Rhomberg, Gradient Corporation, Cambridge, MA

Effects of Superlow Doses
Elena B. Burlakova & Alexander A. Konradov, Russian Academy of Sciences, Moscow, Russia

New Approaches to Modeling of Living Systems Response to Ultra Weak Actions
Elena B. Burlakova, Russian Academy of Sciences, Moscow, Russia

Effects of a ’Lead-free’ Environment on Fertility and Reproductive Function in Female Mice
Ivo Iavicoli, Giovanni Carelli & Nicolo Castellino, Catholic University of the Sacred Heart, Rome, Italy

Pseudo Hormesis: An Explanation in Search of a Manifestation
Susan M. Chemerynski & Jonathen Borak, Yale University, New Haven, CT; Greg
Sirianni, University of New Haven, West Haven, CT; Bernard L. Cohen, University of Pittsburgh, Pittsburgh, PA

Usefulness of Very Low-Doses of Cisplatin in Regulation of Animal and People Health Conditions
Elzbieta Deranalowicz-Malarczyk, Martyna Kandefer-Szerszen, Anna Jarosz-Wilkolazka,
Agnieszka Szuster-Ciesielska & Liliana Borowska, Mareie Curie-Sklodowska University, Lublin, Poland

The Effect of Low-Dose of Guaiacol on Enzymatic Activity of Fungal Cells
Elzbieta Deranalowicz-Malarczyk, Anna Jarosz-Wilkolazka & Janina Kochmanska-Rdest, Marie Curie-Sklodowska University, Lublin, Poland

Ultra-weak Secondary Radiation Chemiluminescence of Humic Acid Induced by Gamma-irradiation
Wieslaw Goraczko & Janusz Slawinski, Poznan Univeristy of Techical, Poznan, Poland

Linear and Non-linear Effects of Lead on Behavior of Drosophila melanogaster
Helmut V.B. Hirsch, John D. Mercer, Tara Torno, Diane Stark & Helen Ghiradella, The University at Albany, SUNY, Albany, NY

Extracellular Replication of Bacteria in Presence of Cytokines or Lipopolysaccharide(LPS): Linear and Non-Linear Responses
Siva Kanangat, Umberto Meduri, Elizabeth A. Tolley, Arnold E. Postlethwaite & Dennise
R. Schaberg, University of Tennessee Memphis, Memphis, TN

A Mathematical Model for Curve-Fitting Allelochemical Dose-Responses
D.L. Liu, NSW Agriculture, Wagga Wagga, NSW, Australia; M. An, Charles Sturt University, Wagga Wagga, NSW Australia; J.V. Lovett, Unversity of New England, Armidale, NSW, Australia

Nectophotometer: A New Instrument for Observing Hormesis
Richard W. Lo Pinto & John Santelli, Fairleigh Dickinson University, Teaneck, NJ

Adaptive Response in Two Populations of Uranium Miners Exposed to Low and High Doses of Radiation
Jose Henrique Pereira Luis, Nuclear and Technological Institute, Sacavem, Portugal

Bimodal Type of Regulation of Protein Kinase C by Antioxidants Down to Ultra-Low Doses
Elena L. Maltseva & Nadya P. Palmina, Institute of Biochemical Physics RAS, Moscow, Russia; Konstantin Gurevich, Lomonosov Moscow University, Moscow, Russia

Adaptation to Radiation: Reductions in Risk after Low Doses in vivo
R.E.J.Mitchel, Atomic Energy of Canada, Ltd, D.R. Boreham, McMaster University

The History of Chemical Hormesis and Potential Implications for Modern Risk Assessment and Epidemiology
Kenneth A. Mundt, Applied Epidemiology, Inc., Amherst, MA
Edward J. Calabrese & Linda A. Baldwin, University of Massachusetts, Amherst, MA

The Development of a Reproducible Toxicological Bioassay to Elucidate Hormesis
Marc A. Nascarella, John G. Stoffolano, Jr. & Edward J. Calabrese, University of Massachusetts, Amherst, MA

Hyperbolic Radiopathogenic Processes for Chernoboyl-touched Children
Eugene A. Neyfakh, Institute of Biochemical Physics, Moscow, Russia

Continuous Low Dose-Rate Gamma-Irradiation Induce Non-Linear Changes of DNA-Protein Cross-Links in Lymphocytes of Mice
Andreyan N. Osipov & Alexander L. Elakov, Moscow SIA "Radon", Moscow, Russia;
Galina Ya. Kolomijtseva, M.V.Lomonosov Moscow State University, Moscow, Russia;
Vyacheslav D. Sypin, Moscow SIA "Radon", Moscow, Russia

The Effect of Antioxidants in Ultra Low Doses on Lipid Peroxide Oxidation in Biological Membranes
Nadezchda P. Palmina, Lyubov V. Kledova & Tatyana V. Pankova, Emanuel Institute of Biochemical Physics RAS, Moscow, Russia

Nonlinear Dose-Response Behavior and Multiple Solutions for a Model of the Menstrual Cycle
Paul M. Schlosser, CIIT Centers for Health Research, Research Triangle Park, NC;
James F. Selgrade & Leona Harris, North Carolina State University, Raleigh, NC

Extremely Low Frequency Electromagnetic Field (ELF-EMF)-Stress Induced DNA Damage in Human Peripheral Blood Leukocytes Evaluated by Comet Assay
Ravindra K. Tiwari, New Science College, Hyderabad, India; K. Irarvathy Goud, Bhagwan Mahavir Medical Research Centre, Hyderabad, India; K. Suryanarayana, Research Center Imarat, Hyderabad, India; S.C Bhargava & Y. Rahuja, Bhagwan Mahavir Medical Research Centre, Hyderabad, India

Non-Linear Dose-Response of Alcohol Drinking in a Large Population
Natalia Udaltsova & Arthur L. Klatsky, Kaiser Permanente Medical Care Program, Oakland, CA

Season of Birth and Human Longevity in a Large Population
Natalia Udaltsova, Gary D. Friedman & Arthur L. Klatsky, Kaiser Permanente Medical Care Program, Oakland, CA; Germaine Cornelissen, Halberg Chronobiology Center, University of Minnisota, Minneapolis, MN; Franz Halberg, Halberg Chronobiology Center, University of Minnisota, Minneapolis, MN

Gamma Variate (Indicator Dilution Curve): Analogy to Describing Selected Hormesis Effects
J.A. Vento & R.P. Spencer, Univ. of Connecticut Health Center, Farmington, CT
  

Conference Scientific
Advisory Board

Iris Bell, M.D., Ph.D., The University of Arizona College of Medicine

Michael P. Bolger, Ph.D., US FDA

Richard Bond, Ph.D., University of Houston

Giovanni Carelli, Ph.D., Catholic University of Sacred Heart, Italy

Peter M. Chapman, Ph.D., EVS Environmental Consultants, Ltd., Canada

George P. Daston, Ph.D., Procter & Gamble Company

David M. Diamond, Ph.D., University of South Florida

Ludwig E. Feinendegen, M.D., Heinrich-Heine-University Duesseldorf, Germany

Donald E. Gardner, Ph.D., Inhalation Toxicology Association

John H. Graham, Ph.D., Berry College, Dept of Biology

A. Wallace Hayes, Ph.D., The Gillette Company

Michael Jayjock, Ph.D., Rohm & Haas

Wayne Jonas, M.D., Samueli Institute, Alexandria, VA

Ralph L. Kodell, Ph.D., NCTR

Walter J. Kozumbo, Ph.D., AFOSR/NL

Shu-Zheng Liu, M.D., Norman Bethune University of Medical Sciences, P.R.China

Werner K. Lutz, Ph.D., University of Wuerzburg, Germany

Harihara M. Mehendale, Ph.D. DABT, Northeast Louisiana University

Ricardo Ochoa, Ph.D., Pfizer

James T. Oris, Ph.D., Miami University

Wim Passchier, Ph.D., Health Council of the Netherlands

Suresh I.S. Rattan, Ph.D., D.Sc., University of Aarhus, Denmark

Denise Robinson, Ph.D., ILSI Health and Environmental Sciences Institute

George M. Rusch, Ph.D., Honeywell International

Leslie Stayner, Ph.D., NIOSH

Kenneth R. Still, Ph.D., MBA, Naval Health Research Center/TD

Elmer Szabadi, Ph.D., Queen’s Medical Center, Div of Psychiatry, UK

Bailus Walker, Jr., Ph.D., MPH, Howard University College of Medicine

Richard Wilson, Ph.D., Harvard University

Raymond Yang, Ph.D., Colorado State University

Nasser H. Zawia, Ph.D., University of Rhode Island

Ed Zillioux, Ph.D., FPL Environmental Services

Conference Sponsors

Air Force

AWWA Research Foundation

CRC Press

Department of Energy

Dow Corning

Environmental Protection Agency

ExxonMobil

Health Canada

Honeywell

NIEHS

Nuclear Regulatory Commission

Pfizer

Philip Morris, Inc.

Radiation Science and Health Center for Nuclear Technology and Society at WPI

Rhom and Haas Company

R. J. Reynolds

Samueli Institute for Information

Texaco

The Jerry Cohen Foundation